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Critical Care Publications

Below are recent publications by faculty members in the Division of Critical Care in the Department of Pediatrics at Northwestern University Feinberg School of Medicine.

Recent PubMed Publications

  1. Bennett TD, Argent AC, Sanchez-Pinto LN  Phoenix Criteria for Pediatric Sepsis and Septic Shock-Reply.  JAMA  2024 May 23;. doi:10.1001/jama.2024.8202
  2. Heneghan JA, Akande MY, Ramgopal S, Evans MD, Hallman M, Goodman DM  New Morbidities During Critical Illness and Associated Risk of ICU Readmission: Virtual Pediatric Systems Cohort, 2017-2020.  Pediatr Crit Care Med  2024 May 23;. doi:10.1097/PCC.0000000000003542
  3. Zurawel AA, Coates BM  Time to split: biomarker trajectories in pediatric acute respiratory distress syndrome hint at underlying disease.  J Clin Invest  2024 May 15;134(10). pii:e180662
  4. Ashworth RC, Malone JR, Franklin D, Sorce LR, Clayman ML, Frader J, White DB, Michelson KN  Associations of Patient and Parent Characteristics With Parental Decision Regret in the PICU: A Secondary Analysis of the 2015-2017 Navigate Randomized Comparative Trial.  Pediatr Crit Care Med  2024 May 10;. doi:10.1097/PCC.0000000000003534
  5. Liu B, Yi D, Li S, Ramirez K, Xia X, Cao Y, Zhao H, Tripathi A, Qiu S, Kala M  et al.  Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension.  bioRxiv  2024 Apr 15;. pii:2024.02.11.579846
  6. Zhang X, Blackwell CK, Moore J, Liu SH, Liu C, Forrest CB, Ganiban J, Stroustrup A, Aschner JL, Trasande L  et al.  Associations between neighborhood characteristics and child well-being before and during the COVID-19 pandemic: A repeated cross-sectional study in the Environmental influences on Child Health Outcomes (ECHO) program.  Environ Res  2024 Mar 27;252(Pt 1):118765. doi:10.1016/j.envres.2024.118765
  7. Atreya MR, Bennett TD, Geva A, Faustino EVS, Rogerson CM, Lutfi R, Cvijanovich NZ, Bigham MT, Nowak J, Schwarz AJ  et al.  Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock.  Pediatr Crit Care Med  2024 Mar 11;. doi:10.1097/PCC.0000000000003499
  8. Sanchez-Pinto LN, Bennett TD, DeWitt PE, Russell S, Rebull MN, Martin B, Akech S, Albers DJ, Alpern ER, Balamuth F  et al.  Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock.  JAMA  2024 Feb 27;331(8):675-686. doi:10.1001/jama.2024.0196
  9. Rissman L, Paquette ET  Family Challenges and Navigator Support: It is Time We Support Our Families Better.  Pediatr Crit Care Med  2024 Feb 01;25(2):180-182. doi:10.1097/PCC.0000000000003403
  10. Tager JB, Hinojosa JT, LiaBraaten BM, Balistreri KA, Aniciete D, Charleston E, Frader JE, White DB, Clayman ML, Sorce LR  et al.  Challenges of Families of Patients Hospitalized in the PICU: A Preplanned Secondary Analysis From the Navigate Dataset.  Pediatr Crit Care Med  2024 Feb 01;25(2):128-138. doi:10.1097/PCC.0000000000003385
  11. Walker SB, Winters JM, Schauer JM, Murphy P, Fawcett A, Sanchez-Pinto LN  Performance of Tools and Measures to Predict Fluid Responsiveness in Pediatric Shock and Critical Illness: A Systematic Review and Meta-Analysis.  Pediatr Crit Care Med  2024 Jan 01;25(1):24-36. doi:10.1097/PCC.0000000000003320
  12. Prigge AD, Coates BM  Can Airway Monocytes from Premature Infants Teach Us about Macrophage Differentiation in the Lungs?  Am J Respir Cell Mol Biol  2023 Dec;69(6):612-613. doi:10.1165/rcmb.2023-0305ED
  13. Rogerson CM, Abu-Sultaneh S, Loberger JM, Ross P, Khemani RG, Sanchez-Pinto LN  Predicting Duration of Invasive Mechanical Ventilation in the Pediatric ICU.  Respir Care  2023 Nov 25;68(12):1623-1630. doi:10.4187/respcare.11015
  14. Dai Z, Thorp EB  New Way to Study Pulmonary Hypertension in HFpEF.  Circ Res  2023 Nov 10;133(11):899-901. doi:10.1161/CIRCRESAHA.123.323753
  15. Wösten-van Asperen RM, la Roi-Teeuw HM, van Amstel RB, Bos LD, Tissing WJ, Jordan I, Dohna-Schwake C, Bottari G, Pappachan J, Crazzolara R  et al.  Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes-an international multicentre retrospective study.  EClinicalMedicine  2023 Nov;65:102252. pii:102252
  16. Zhao Y, Li C, Zhang S, Cheng J, Liu Y, Han X, Wang Y, Wang Y  Inhaled nitric oxide: can it serve as a savior for COVID-19 and related respiratory and cardiovascular diseases?  Front Microbiol  2023;14:1277552. pii:1277552
  17. Sanchez-Pinto LN, Bhavani SV, Atreya MR, Sinha P  Leveraging Data Science and Novel Technologies to Develop and Implement Precision Medicine Strategies in Critical Care.  Crit Care Clin  2023 Oct;39(4):627-646. doi:10.1016/j.ccc.2023.03.002
  18. Machut KZ, Gilbart C, Murthy K, Michelson KN  A Qualitative Study of Nurses' Perspectives on Neonatologist Continuity of Care.  Adv Neonatal Care  2023 Oct 01;23(5):467-477. doi:10.1097/ANC.0000000000001096
  19. Sanchez-Pinto LN, Bennett TD, Stroup EK, Luo Y, Atreya M, Bubeck Wardenburg J, Chong G, Geva A, Faustino EVS, Farris RW  et al.  Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock.  Pediatr Crit Care Med  2023 Oct 01;24(10):795-806. doi:10.1097/PCC.0000000000003292
  20. Zhou Z, Zhang Y, Tan C, Zhang J, Yi G, Wang B, Li Y, Lu H, Lu W, Zhang X  The long non-coding RNA BBOX1 antisense RNA 1 is upregulated in polycystic ovary syndrome (PCOS) and suppresses the role of microRNA-19b in the proliferation of ovarian granulose cells : Short title: BBOX1 antisense RNA 1 in cell proliferation.  BMC Womens Health  2023 Sep 21;23(1):508. pii:508
  21. Stephen RJ, Lucey K, Carroll MS, Hoge J, Maciorowski K, Jones RC, O'Connell M, Schwab C, Rojas J, Sanchez Pinto LN  Sepsis Prediction in Hospitalized Children: Clinical Decision Support Design and Deployment.  Hosp Pediatr  2023 Sep 01;13(9):751-759. doi:10.1542/hpeds.2023-007218
  22. Stephen RJ, Carroll MS, Hoge J, Maciorowski K, Jones RC, Lucey K, O'Connell M, Schwab C, Rojas J, Sanchez-Pinto LN  Sepsis Prediction in Hospitalized Children: Model Development and Validation.  Hosp Pediatr  2023 Sep 01;13(9):760-767. doi:10.1542/hpeds.2022-006964
  23. Zhang X, Brody JA, Graff M, Highland HM, Chami N, Xu H, Wang Z, Ferrier K, Chittoor G, Josyula NS  et al.  WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE.  medRxiv  2023 Aug 22;. pii:2023.08.21.23293271
  24. Atreya MR, Bennett TD, Geva A, Faustino EVS, Rogerson CM, Lutfi R, Cvijanovich NZ, Bigham MT, Nowak J, Schwarz AJ  et al.  External validation and biomarker assessment of a high-risk, data-driven pediatric sepsis phenotype characterized by persistent hypoxemia, encephalopathy, and shock.  Res Sq  2023 Aug 02;. pii:rs.3.rs-3216613
  25. Zhang X, Young C, Liao XH, Refetoff S, Torres M, Tomer Y, Stefan-Lifshitz M, Zhang H, Larkin D, Fang D  et al.  Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland.  JCI Insight  2023 Jun 22;8(12). pii:e169937
  26. Siddiqui MR, Reddy NM, Faridi HM, Shahid M, Shanley TP  Metformin alleviates lung-endothelial hyperpermeability by regulating cofilin-1/PP2AC pathway.  Front Pharmacol  2023;14:1211460. pii:1211460
  27. Zhao Y, Han X, Li C, Liu Y, Cheng J, Adhikari BK, Wang Y  COVID-19 and the cardiovascular system: a study of pathophysiology and interpopulation variability.  Front Microbiol  2023;14:1213111. pii:1213111
  28. Premkumar A, Fry JT, Bolden JR, Grobman WA, Michelson KN  The value and limitations of using predetermined criteria in decision making for maternal-fetal interventions.  Prenat Diagn  2023 Jun;43(6):792-797. doi:10.1002/pd.6363
  29. Pendergrast TR, Chapin CA, Kriegermeier AA, Pardo AC, Bass LM, Sanchez-Pinto LN  Heart rate variability is associated with encephalopathy and outcomes in pediatric acute liver failure.  Pediatr Res  2023 Apr;93(5):1348-1353. doi:10.1038/s41390-022-02225-2
  30. Rissman L, Derrington S, Michelson KN  Prognostic Conversations Between Parents and Physicians in the Pediatric Intensive Care Unit.  Am J Crit Care  2023 Mar 01;32(2):118-126. doi:10.4037/ajcc2023729
  31. Sanchez-Pinto LN, Sauthier M, Rajapreyar P, Brunow de Carvalho W, Jouvet P, Newth C,   Leveraging Clinical Informatics and Data Science to Improve Care and Facilitate Research in Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.  Pediatr Crit Care Med  2023 Feb 01;24(12 Suppl 2):S1-S11. doi:10.1097/PCC.0000000000003155
  32. Divakar A, James K, Mayorga A, Michelson KN  Availability of bereavement support following traumatic pediatric death in a large metropolitan area.  Death Stud  2023;47(10):1127-1135. doi:10.1080/07481187.2023.2170492
  33. Olszewski AE, Mendelsohn L, Paquette ET  Unique Ethical and Practical Considerations in the Use of Behavior Contracts for Families of Minors and Minoritized Populations in Pediatric Settings.  Am J Bioeth  2023 Jan;23(1):82-85. doi:10.1080/15265161.2022.2146796
  34. Walker SB, Badke CM, Carroll MS, Honegger KS, Fawcett A, Weese-Mayer DE, Sanchez-Pinto LN  Novel approaches to capturing and using continuous cardiorespiratory physiological data in hospitalized children.  Pediatr Res  2023 Jan;93(2):396-404. doi:10.1038/s41390-022-02359-3
  35. Perizes EN, Chong G, Sanchez-Pinto LN  Derivation and Validation of Vasoactive Inotrope Score Trajectory Groups in Critically Ill Children With Shock.  Pediatr Crit Care Med  2022 Dec 01;23(12):1017-1026. doi:10.1097/PCC.0000000000003070
  36. Goodman DM, Casale MT, Rychlik K, Carroll MS, Auger KA, Smith TL, Cartland J, Davis MM  Development and Validation of an Integrated Suite of Prediction Models for All-Cause 30-Day Readmissions of Children and Adolescents Aged 0 to 18 Years.  JAMA Netw Open  2022 Nov 01;5(11):e2241513. pii:e2241513
  37. Zhang X, Liu SH, Geron M, Mathilda Chiu YH, Gershon R, Ho E, Huddleston K, Just AC, Kloog I, Coull BA  et al.  Prenatal exposure to PM2.5 and childhood cognition: Accounting for between-site heterogeneity in a pooled analysis of ECHO cohorts in the Northeastern United States.  Environ Res  2022 Nov;214(Pt 4):114163. doi:10.1016/j.envres.2022.114163
  38. Madrigal V, MacDuffie K, Paquette ET  Addressing Racism in the Healthcare Encounter: The Role of Clinical Ethics Consultants.  J Clin Ethics  2022;33(3):202-209
  39. Koch CM, Prigge AD, Setar L, Anekalla KR, Do-Umehara HC, Abdala-Valencia H, Politanska Y, Shukla A, Chavez J, Hahn GR  et al.  Cilia-related gene signature in the nasal mucosa correlates with disease severity and outcomes in critical respiratory syncytial virus bronchiolitis.  Front Immunol  2022;13:924792. pii:924792
  40. Michelson KN, Arenson M, Charleston E, Clayman ML, Brazg T, Rychlik K, Rosenberg AR, Frader J  Parental Views of Social Worker and Chaplain Involvement in Care and Decision Making for Critically Ill Children with Cancer.  Children (Basel)  2022 Aug 26;9(9). pii:1287
  41. Zhang X, Yamada Y, Sagayama H, Ainslie PN, Blaak EE, Buchowski MS, Close GL, Cooper JA, Das SK, Dugas LR  et al.  Human total, basal and activity energy expenditures are independent of ambient environmental temperature.  iScience  2022 Aug 19;25(8):104682. pii:104682
  42. Paquette ET  Reckoning With Redlining and Other Structural Barriers to Health of Critically Ill Children: Addressing Systemic Racism Will Require Shifting the Focus From Micro- to Macrolevel Analysis of Social Risks.  Pediatr Crit Care Med  2022 Aug 01;23(8):662-665. doi:10.1097/PCC.0000000000003016
  43. Smith CM  Late-Onset Neurologic Dysfunction in Pediatric Sepsis-What Brains Might Learn From Kidneys and Persistent Acute Kidney Injury.  Pediatr Crit Care Med  2022 Aug 01;23(8):659-661. doi:10.1097/PCC.0000000000003007
  44. Zhao Y, Yu Y, Wang H, Li Y, Deng Y, Jiang G, Luo Y  Correction to: Machine Learning in Causal Inference: Application in Pharmacovigilance.  Drug Saf  2022 Aug;45(8):927. doi:10.1007/s40264-022-01199-8
  45. Michelson KN, Klugman CM, Kho AN, Gerke S  Ethical Considerations Related to Using Machine Learning-Based Prediction of Mortality in the Pediatric Intensive Care Unit.  J Pediatr  2022 Aug;247:125-128. doi:10.1016/j.jpeds.2021.12.069
  46. Zhang X, Lv J, Liu P, Xie X, Li X, Zhang H, Jin J  Serological Measurement of Poly-IgA Immune Complex Levels in IgA Nephropathy and IgA Vasculitis.  Bio Protoc  2022 Jul 05;12(13). pii:e4463
  47. Eickelberg G, Luo Y, Sanchez-Pinto LN  Development and validation of MicrobEx: an open-source package for microbiology culture concept extraction.  JAMIA Open  2022 Jul;5(2):ooac026. pii:ooac026
  48. Zhang X, Lucas AM, Veturi Y, Drivas TG, Bone WP, Verma A, Chung WK, Crosslin D, Denny JC, Hebbring S  et al.  Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders.  Nat Commun  2022 Jun 14;13(1):3428. pii:3428
  49. Dalabih AR, Prodhan P, Harris ZL, Bone MF  Employment Opportunities for Pediatric Critical Care Fellowship Trained Physicians in the United States.  J Pediatr Intensive Care  2022 Jun;11(2):105-108. doi:10.1055/s-0040-1716908
  50. Badke CM, Carroll MS, Weese-Mayer DE, Sanchez-Pinto LN  Association Between Heart Rate Variability and Inflammatory Biomarkers in Critically Ill Children.  Pediatr Crit Care Med  2022 Jun 01;23(6):e289-e294. doi:10.1097/PCC.0000000000002936

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