Critical Care Research

The following list represents some of the breadth of research efforts in the Division of Critical Care in the Department of Pediatrics at Northwestern University Feinberg School of Medicine. Learn more by visiting our page on the Ann & Robert H. Lurie Children's Hospital of Chicago website.

Search our listing of current clinical trials and review our recent publications for more information.

Clinical Research

End-of-life care and decision-making in the ICU
Assessment tools for palliative care in the ICU
Family communication in the PICU
Bereavement needs in the PICU
Social determinants of health impact on PICU care
Predictors of enrollment of racially and ethnically diverse participants in emergency and critical care research
Informed consent in the PICU
Circadian rhythm and sleep disturbances in the PICU
Energy expenditure in critical illness

Basic Science Research

Determinants of endothelial permeability
Determinants of transendothelial migration
Dissecting the inflammasome
Investigating the role of innate immune responses in influenza infection and elucidation of the mechanisms underlying age-related susceptibility
MerTK and cardiac macrophage interactions following myocardial ischemia
Epigenetic changes of anthracyclines on cardiac stem cells
Impact of microbiome on premature delivery

Translational Research

Transcriptome profiling of pediatric cardiac stem cells
Adrenal responsiveness in children undergoing congenital cardiac surgery
Quantification of histone deacetylase-2 activity in pediatric ARDS
ABC cassette mutations, seizure disorders and sensitivity to antiepileptic medications
Sepsis and predictive analytics
Precision medicine and critical care
Metabolic cocktails and critical care outcomes
Early warning systems, autonomic function and real-time analytics
Data-driven phenotypes of critical illness though clinical, physiologic and multi-omics data integration
Pharmacometric interpretation of both population and clinical trial data